A Mems Micropump System with One-way Valve for Chronic Drug Delivery
نویسندگان
چکیده
Implantable micropump systems capable of user-controlled and site-specific chronic drug delivery in small animals are a critical unmet need in drug discovery and development. Our electrochemical bellows actuator provides current-controlled flow rate and is integrated to form a fully implantable system with a refillable reservoir and one-way valve that prevents mixing of biological fluids with the drug. Periodic dosing performance was demonstrated with minimal reverse leakage through the valve and flow rate error of no more than 3-10%. Similar performance was obtained using a wireless micropump driven using a Class E inductively coupled powering system for remote on/off control.
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